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In addition to partial agonist activity at the D2 receptor, aripiprazole is also a partial agonist at the 5-HT1A receptor, and like the other atypical antipsychotics, aripiprazole displays an antagonist profile at the 5-HT2A receptor.

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One problem with most of the studies that evaluate these medications is that often more than half the patients discontinue the drugs either because of side effects or because they do not feel the medications are helping them.

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University of Pittsburgh School of Medicine, and his colleagues tested the effectiveness and safety of aripiprazole as an adjunctive therapy to venlafaxine in 468 adults aged 60 and over with no history of cognitive deficits.

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Risk of orthostatic hypotension associated with adverse effects, including postural dizziness and syncope, perhaps because of aripiprazole's α 1-adrenergic blocking activity.

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